Cholesteatoma: How it grows and where it goes, and how we should therefore approach its surgery: An analysis of data collected prospectively on 516 cases.

Global health funding: how much, where it comes from and where it goes.

Global health funding has increased in recent years. This has been accompanied by a proliferation in the number of global health actors and initiatives. This paper describes the state of global heath finance, taking into account government and private sources of finance, and raises and discusses a number of policy issues related to global health governance. A schematic describing the different ...

Colour : How We See It and How We Use It

Sympathovagal balance: how should we measure it?

There are complex interactions between the sympathetic and parasympathetic nervous system inputs to the sinus node. The concept of "sympathovagal balance" reflects the autonomic state resulting from the sympathetic and parasympathetic influences. Despite widespread usage of a variety of heart rate (HR) variability parameters as indexes of sympathovagal balance, no index has been validated as a ...

Should we treat pyrexia? And how do we do it?

The concept of pyrexia as a protective physiological response to aid in host defence has been challenged with the awareness of the severe metabolic stress induced by pyrexia. The host response to pyrexia varies, however, according to the disease profile and severity and, as such, the management of pyrexia should differ; for example, temperature control is safe and effective in septic shock but ...

Linezolid for multidrug-resistant tuberculosis: How should we approach it?

Multidrug-resistant tuberculosis (MDR-TB), defined as resistance to at least rifampicin and isoniazid, poses a major threat to public health and TB control worldwide. According to the World Health Organization (WHO), MDR-TB accounted for 480,000 new cases of TB in 2013, of which 9% were extensively drug-resistant TB (XDR-TB), defined as MDR-TB with resistance to a fluoroquinolone and at least o...